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Goodbye hyperpigmentation, hello glow!

Take our 2-minute Skin Test, and get your customized formulation.
(30% off TODAY ONLY)


Already submitted your Skin Test? Amazing! Head straight for the checkout, where your customized formulation awaits!

Checkout Now - £45.50 £65.00

Say goodbye to hyperpigmentation

Reply to few questions and get your custom formula and 30% Off (Today only)


You already submited your skin test ? Great! simply checkout and we will send your customized formulation.

Checkout Now - £45.50 £65.00


Become a poster child for bright skin.

Gone are the days of the 'trial and error' process and feeling the need to constantly hide your skin behind heavy makeup.

We’ve created a concentrated serum that's calibrated for you to meet your specific skin needs. And now with the right products within your grasp, we can guarantee only brighter skin days ahead.

Our research reveals...

Why most anti-hyperpigmentation serums don’t work on your melanin-rich skin.

Most brightening serums are either too strong and will trigger excess melanin production, causing more hyperpigmentation.

Or, they use the single-star ingredient approach, which may work on lighter skin, but not on your melanin-rich skin.

Treating hyperpigmentation in melanin-rich skin requires both a gentle, yet multi-tiered approach to ensure that all avenues for producing excess melanin are addressed.

4.5.6 Solution

👍🏽 Researched and tested on melanin-rich skin
👍🏽 Designed with a multi-tiered ingredients approach
👍🏽 Customized to your melanin levels
👍🏽 Freshly made-to-order


Mainstream Solutions

👎🏻 Not researched or tested on melanin-rich skin
 👎🏻 Not designed with a multi-tiered ingredient approach
 👎🏻 Not customized to your melanin levels
 👎🏻 Not freshly made-to-order

The 4.5.6 Solution

👍🏽 Researched and tested on melanin-rich skin
👍🏽 Designed with a multi-tiered ingredient approach
👍🏽 Customized to your exact melanin levels
👍🏽 Freshly made-to-order for optimum results

We’re all about your melanin

The unique functions and structure of your melanin-rich skin are at the heart of our scientific process. You are the star of our show.

We’re scientifically led

 Our team of skin chemists use their two decades of experience creating prescriptive skincare to make natural brightening blends just for you.

We’re custom-made

You shouldn't have to settle for ‘one size fits all!’ Whether you’re a phototype IV, V or VI, we'll create a serum that fits your skin type, and your level of hyperpigmentation.

Cruelty and harm free

We're committed to using only the highest standard of biodynamic ingredients, and of course, we do not test on animals.

No endocrine disruptors

Endocrine disruptors like phenoxyethanol can negatively affect your hormonal health and your fertility. So that's a 'no' from us. 


We always prioritize environmentally responsible ingredients that respect the integrity of your skin, your health, and the planet.

80% of our customers reported more uniform, healthier, brighter skin after using our Sevenly Delight Brightening Concentrated Serum.

This is thanks to a gentle (but powerful) synergy of:

  • Biodynamic active ingredients that help balance pigmentation, while preventing and fading hyperpigmentation. 
  • Seven brightening active ingredients that tackle excess melanin production through seven melanin pathways. 
  • Antioxidants that scavenge free-radicals that may cause inflammation, and therefore trigger hyperpigmentation.
  • A combination of gentle  chemicals and enzymatic exfoliators that will maintain healthy cell renewal.
  • Soothing agents that keep hyperpigmentation-triggering inflammation at bay.
  • Moisturizers, humectants, and emollients to keep your skin nourished and hydrated. 

How is your Sevenly Delight Brightening Serum made?

First, our skin chemists 
create a core blend.

What's in the core blend?

Key active ingredients:

Vitalized Water, Radish Root Extract, Almond Oil, and Royal Jelly:
 Emollients and humectants that deeply nourish the skin.

Vitamin C, Vitamin B6, Astaxanthin, Cichorium Root Extract: Vitamins and antioxidants with powerful skin brightening effects. 

Lilium Candidum Extract: Prevents and reduces brown spots, skin blemishes, and hyperpigmentation, along with increasing cell regeneration.

Niacinamide: Reduces inflammatory response, while reducing post-acne scars and dark spots.

Azelaic Acid: Blocks the main process in the formation of hyperpigmentation, unifies the complexion, and exfoliates the skin for a radiant glow. 

Salicylic Acid, Citric Acid, Lactic Acid: AHA's and BHA's that slough away dead skin cells, brighten an uneven complexion, and gently treat acne breakouts.

(Order today to receive your freshly-made serum + free shipping)

Then, they boost the core blend with the below actives for a maximized brightening effect.

We add various concentrations and combinations of brightening ingredients (and more) in the core blends to customize each serum to your melanin levels, skin type, and specific skin concerns.

Hydrolysed thapus flower

Protects skin from harmful high-energy UV rays and adds radiance to the skin


Acts as an effective tyrosinase inhibitor which provides the skin with lightning and brightening effects.

Palmaria palmata

This red algae Inhibits the melano-genesis and controls photoinduced pigmentation to leave the skin uniform.

Balanite roxburghii oil

This biocompatible active uses the palmoplantar melanin regulation pathway to brighten the skin and fight the many factors that cause hyperpigmentation.


A bioactive that inhibit tyrosinase by turning Eumelanin ( darker/ melanin) into Pheomelanin ( lighter melanin).


Full to the brim with vitamin C, it eliminates free radicals to efficiently brighten and even out the complexion.

Hydrolysed Thapus Flower

Protects skin from harmful high-energy UV rays and adds radiance to the skin.

Alpha Arbutin

An effective tyrosinase inhibitor, which provides the skin with lightening and brightening effects.

Palmaria Palmata

This red algae inhibits the melano-genesis and controls photoinduced pigmentation to leave the skin looking uniform.

Balanite Roxburghii Oil

This biocompatible active uses the palmoplantar melanin regulation pathway to brighten the skin and fight the many factors that cause hyperpigmentation.

Acerola Extract 

Full to the brim with vitamin C, it eliminates free radicals to effectively brighten and even out the complexion.


A bioactive ingredient that inhibits tyrosinase enzymes by turning Eumelanin (darker melanin) into Pheomelanin (lighter melanin).

They’re getting their desired results!

"I've been using this for 4 weeks now, and I'm really loving it.
It says my name on it, and it feels like 4.5.6 is catering to my skin! 🙌🏽 Darker skin needs a strong, yet gentle blend of ingredients to clear hyperpigmentation that settles below the skin—and the traditional skincare industry doesn't make them strong enough for darker tones.⁠ ⁠Using the right serum for your skin type is a game-changer."
Auri, phototype V


"Along with getting a facial one every two months, that and using 4.5.6 has been a saviour. Thank you for making skincare for melanin skin also, nice to have been thought of."


"Since I have started using this product, my dark spots have begun to fade and skin tone has begun to even out. I’m so happy I invested in my skin, and am even happier there is a product out there for my skin type. Thank you so much."

 Crystal Waugh

"I have used so many brands using Space NK. My big sister, a cosmetic, skin care consultant, taught me the importance of face creams. Now I can tell her about these brilliant product, 4.5.6. My skin has never looked this great." 

 Ms Ratbag

"The initial couple weeks, my skin had a few breakouts, but I was warned that this may happen. My skin is now much brighter and the excessive oil that had been a problem is slowly but surely reducing."

 Aya Shili

"I have been using the set for just under a month and have noticed a significant change in my glow and surface of my skin. I no longer have really oily skin, first thing in the morning like I used to, instead I wake up to a natural glow."


"Absolutely love these products and will certainly be repurchasing. I’ve also seen a difference in my skin after using each product, especially the cleansing gel and the To Be Clear Exfoliant Mask. My skin loves it."

 Belle Mbwese

Ready to customize your brightening routine? 

You take the Skin Test

Take our 2-minute Skin Test to help us understand your specific skin needs.

We determine the ideal dose for your customization actives

We’ll calculate your answers to determine the ideal formulation. So say goodbye to hyperpigmentation, once and for all!

We custom-make your formula

Our team of chemists will freshly-make your custom formulation, then we’ll deliver it straight to your door.

The skincare team that will always put you first.

Our co-founder Noelly Michoux is a luxury beauty business expert on a mission to uplift women through healthy skin.

She co-founded 4.5.6 Skin with Imen Jerbi Phd, a doctor in Pharmacy and skin researcher, with a 15-year career in formulating prescriptive skincare for darker skin tones.

Along with Dr Carlos A. Charles, MD a board-certified dermatologist and Clinical Instructor of Dermatology specializing in darker skin tones.

With a health-centric approach to skincare, our team is dedicated to finding healthy solutions for melanin-rich skin. We don't compromise when it comes to the health of your melanin-rich skin.

How to use our serum.

Apply 3 pumps onto freshly cleansed skin (before your moisturizer), and massage in circular motions until fully absorbed.

This serum contains Azelaic Acid, a gentle exfoliator that excels at removing dead skin cells to smooth skin texture, reduce pore size, and minimize acne-breakouts.

Due to its exfoliating nature, be very gentle with your application as to uphold the integrity of your protective skin barrier.

Can be used daily for your morning and nighttime routines.

Frequently Asked Questions.