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Revolutionising skin care for darker skin tones


We spent three years building the world’s first Skin Tone Research Lab to test, develop and manufacture high performance products based on the functional and physiological differences of phototypes IV, V, and VI.

Focusing on hyperpigmentation, dullness, dehydration and sensitivity as it uniquely affects darker skin, our aim is to democratize the foundations of skincare research and development.


We started from scratch

Using this game-changing approach, 4.5.6 Skin was born. A clean, hyper-balanced, anti-inflammatory skincare system rooted in the science of skin tone.

Representing all skin tones in skin care

How We Revolutionised Skin Tone Research

Groundbreaking Skin Research

1. Groundbreaking skin research

Testing and Manufacturing Skincare

2. Testing and manufacturing

Innovative skin care

3. Innovating

Groundbreaking Skin Research

4. Customisation & Implementing feedback from our 4.5.6 community

Science backed skincare is our speciality.
And we are 100% uncompromising.


Creating change through science

As experts on melanin-rich skin, we are combining our love of science and nature to ensure everyone feels seen, heard and represented.

Phototype VI

Noelly Michoux

Noelly Michoux


Born in Cameroon and raised in Normandy, France, Noelly, a former beauty e-commerce director, experienced the skincare struggle firsthand while moving across Europe and the USA.

 Fueled by passion and empathy, she partnered with top scientists to create effective and safe clinical skincare developed from the ground up for darker skin while promoting research equity for all skin types. Noelly believes beauty starts with knowing yourself!

Phototype V

Dr Carlos A. Charles MD

Dr Carlos A. Charles MD


Dr. Carlos Charles, MD, is a board-certified dermatologist, clinical instructor at Weill Medical College, and Fellow of the American Academy of Dermatology. He founded Derma di Colore in 2012, a dermatology practice specializing in treating dermatologic problems in all skin types, with a focus on darker skin tones. Derma di Colore also conducts national clinical research studies to address challenging dermatologic issues in pigmented skin.

Phototype IV

Imen Jerbi Phd

Imen Jerbi Phd

CO-FOUNDER AND Chief Scientist

Imen, 'the skin healer,' is a Doctor of Pharmacy, with 15 years of experience in skin research, formulating skincare, haircare, and nutraceuticals for darker skin tones. With a health-centric approach and expertise in ethnobotany, she is dedicated to inclusive and healthy skin solutions. Imen's unwavering commitment to skin health prioritises natural remedies and a belief in achieving results without compromising skin or overall health.

The Science of Skin Tone, Powered By Nature With No Compromises

The Science of Skin Tone, Powered By Nature With No Compromises


Your Skin, New Rules

There is more to skin than lightness or darkness. A limited understanding of how to care for different skin tones has led to many misconceptions. We are here to challenge the status quo and foster a new era of understanding.


The 4.5.6 Method

With thousands of hours of research and testing, our core principles are at the heart of everything we do

Our Vitalised Water

Up to 70% of water can be found in water-based products, making it a main ingredient

It improves ingredient efficacy by allowing deeper penetration into the skin

Our Vitalised water works with darker skin, rather than against it

It energetically charges skin cell metabolism, treating dullness, dehydration and improving skin barrier function

Renowned for its transformative properties on darker skin.

The Master Complex

Perfectly balanced for efficacy, the 4.5.6 Master Complex is a combination of actives that include:

Ingredients that build up the natural skin antioxidant capital and reduce oxidative stress

Mild non-ionic and natural derived emulsifiers

Non aggressive exfoliators with anti-inflammatories

Melanin inhibitors and pigmentation rebalancing actives

Therapeutic oils and botanical extracts rich in anti-inflammatories and essential nutrients

Microbiota preserving actives

Vitamin D like actives to increase the skin's immune system


Dermalogically tested

Safely treats hyperpigmentation

Conscious Packaging

Regulates sebum production

Conscious Packaging

Revitalises and nourishes skin

Certified Halal

Strengthens and repairs the skin barrier

Max Glow Getter Serum


Minimising Our Impact

Our products are

Compliant with clean beauty standards like Good Face- We avoid extra packaging. They are formulated without ingredients that are harmful to human health or the environment

We are focused on transparency and ethical practices that incorporate the latest science relating to skin ingredients. Our products contain natural and synthetic ingredients which are proven to be safe in accordance with health and safety standards and across international regulatory principles around the world.

We reduce pollution by using green chemistry principle. We do an automatic ban of hazardous chemicals and even suspected ones. We boost innovation for safe and sustainable natural biodegradable ingredients. We apply sustainability in our products full life cycle.

Use coupon code WELCOME10 for 10% off your first order.

Our products are made fresh to order, because of this and issues with Brexit, it can take up to 10 days for your order to arrive. If you want a quicker service, you can choose to ship via DHL at the checkout. We are sorry for any inconvenience that this may cause.


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